【Benefits】

• Alleviation of knee joint pain and rheumatic pain

【Precaution step】

• Since we are using natural ingredients, color unevenness and spots may occur, but there is no problem with the quality.
• Please use it as soon as possible after opening to avoid affecting the quality.
• Keep out of reach of small children.

Without destroying the molecular structure by high temperature, film type products represent the world’s first exclusive manufacturing method by Thanks Ai

This premium product contains high quality collagen extracted from the nasal cartilage of exclusively selected natural salmon in Hokkaido, which is well-known for its richness in nature. Collagen is the most abundant protein in human body, found in skin, bones, muscles, and tendons. It forms a scaffold to provide strength and structure. Our technology ensures that the molecular structure of collagen is not destroyed by high temperature and its activity and function is preserved to the fullest. Furthermore, by using our multinational patented extraction technology, the collagen content can achieve a purity as high as 75%.

Science

• Gencoglu, H., Orhan, C., Sahin, E., & Sahin, K. (2020). Undenatured Type II Collagen (UC-II) in Joint Health and Disease: A Review on the Current Knowledge of Companion Animals. Animals : an open access journal from MDPI, 10(4), 697. https://doi.org/10.3390/ani10040697
• Christiane Schön, Katharina Knaub, Wilfried Alt, Shane Durkee, Zainulabedin Saiyed, and Vijaya Juturu. UC-II Undenatured Type II Collagen for Knee Joint Flexibility: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Clinical Study. Journal of Integrative and Complementary Medicine. Jun 2022.540-548. http://doi.org/10.1089/jicm.2021.0365
• Lugo, J. P., Saiyed, Z. M., Lau, F. C., Molina, J. P., Pakdaman, M. N., Shamie, A. N., & Udani, J. K. (2013). Undenatured type II collagen (UC-II®) for joint support: a randomized, double-blind, placebo-controlled study in healthy volunteers. Journal of the International Society of Sports Nutrition, 10(1), 48. https://doi.org/10.1186/1550-2783-10-48
• Schön, C., Knaub, K., Alt, W., Durkee, S., Saiyed, Z., & Juturu, V. (2022). UC-II Undenatured Type II Collagen for Knee Joint Flexibility: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Clinical Study. Journal of integrative and complementary medicine, 28(6), 540–548. https://doi.org/10.1089/jicm.2021.0365
• Lugo, J.P., Saiyed, Z.M. & Lane, N.E. Efficacy and tolerability of an undenatured type II collagen supplement in modulating knee osteoarthritis symptoms: a multicenter randomized, double-blind, placebo-controlled study. Nutr J 15, 14 (2015). https://doi.org/10.1186/s12937-016-0130-8
• Oentarini Tjandra, Shirly Gunawan, Johan Johan, Fia Fia Lie, Marcella Erwina Rumawas, Agus Limarta. Efficacy and Safety of Undenatured Type II Collagen in The Treatment of Osteoarthritis of The Knee: A Randomized, Double-blind, Placebo-controlled Trial. Indones Biomed J. 2023; 15(3): 277-86. https://doi.org/10.18585/inabj.v15i3.2348
• David Sadigursky, Victor Filardi Stolze Magnavita, Cloud Kennedy Couto de Sá, Henrique de Sousa Monteiro, Oddone Freitas Melro Braghiroli, Marcos Antônio Almeida Matos. Undenatured Collagen Type II For The Treatment Of Osteoarthritis Of The Knee. Acta Ortop Bras.2022;30(2):e240572. https://doi.org/10.1590/1413-785220223002240572
• Saiyed, Z., Durkee, S., Bowman, J. and Juturu, V. (2021), Efficacy of UC-II® undenatured type II collagen on knee joint function in healthy subjects: an exploratory post hoc analyses of a randomized double blind, placebo – controlled trial. The FASEB Journal, 35:. https://doi.org/10.1096/fasebj.2021.35.S1.03942
• Crowley DC, Lau FC, Sharma P, Evans M, Guthrie N, Bagchi M, Bagchi D, Dey DK, Raychaudhuri SP. Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial. Int J Med Sci 2009; 6(6):312-321. doi:10.7150/ijms.6.312. https://www.medsci.org/v06p0312
• Costa, A.P., Monteiro, C., Teixeira, V.C. et al. Correlation Between Muscle Strength and Functional Improvement After a Neuromuscular Electrical Strengthening Associated with Undenatured Type II Collagen in Knee Osteoarthritis. SN Compr. Clin. Med. 3, 1122–1132 (2021). https://doi.org/10.1007/s42399-021-00830-6
• Santana, É.T.N., da Cunha Machado, S., Brandão Lima, V.N. et al. Comparison between exercise therapy and non-hydrolyzed collagen (UC-II) in functionality and quality of life in women with knee osteoarthritis. Wien Klin Wochenschr 135, 291–300 (2023). https://doi.org/10.1007/s00508-022-02037-8
• Shiojima, Y., Takahashi, M., Takahashi, R., Maruyama, K., Moriyama, H., Bagchi, D., … Akanuma, M. (2023). Efficacy and Safety of Dietary Undenatured Type II Collagen on Joint and Motor Function in Healthy Volunteers: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study. Journal of the American Nutrition Association, 42(3), 224–241. https://doi.org/10.1080/07315724.2021.2024466
• Luo, C., Su, W., Song, Y., & Srivastava, S. (2022). Efficacy and safety of native type II collagen in modulating knee osteoarthritis symptoms: a randomised, double-blind, placebo-controlled trial. Journal of experimental orthopaedics, 9(1), 123. https://doi.org/10.1186/s40634-022-00559-8
• Rong Xu, Jianping Wu, Lin Zheng, Mouming Zhao. Undenatured type II collagen and its role in improving osteoarthritis. Ageing Research Reviews, Volume 91, 2023, 102080, ISSN 1568-1637. https://doi.org/10.1016/j.arr.2023.102080