Manufactured by the factory of Thanks Ai Co., Ltd., which utilise high-purity proteoglycans that extracted by the world-patented LPT alkali extraction method, as well as lightweight the products with the latest technology, subvert the image of existing cosmetic product in the market. The natural and safe proteoglycan will help you achieve a better quality of life!

Product Name	Profil®
Ingredients	Pullulan, Soluble proteoglycan, Glycerin, Sorbitan Fatty Acid Ester, Cellulose
Content	15 sheets per pack

 

Proteoglycan - Recognised by the Medical Community

"Medical Group Japanese Association of Preventative Medicine for Adult Diseases" will only recommend the excellent products with "quality and safety" as priority to the consumers.
The recommended review includes product specifications, raw material quality (whether it is a natural ingredient), the liability of the product description, the safety of the product to human body, the product itself, the sales type of the product, and the corporate advertisement (consumer safety as first priority), from the beginning to the interview with operator, there will be a total of 8 processes, 20 projects of review, the products will only be launched after going through the final stage, which is obtained the recognition from the board of directors via a comprehensive review. And in the field of each product, there is only one product or one company will be selected as a representative.

 

The Recommendation from Medical Group - Japanese Association of Preventative Medicine for Adult Diseases

Japanese Association of Preventative Medicine for Adult Diseases The association was established in 1988 by the doctors from Tokyo Metropolitan Health and Medical Information Center and the directors of the Physician Cooperative in Tokyo region. A group of medical practitioners and physicians of specialised field, supported by group of scholars and private sectors, aiming to prevent diseases (civilized diseases) and establish a healthy society through free consultation and assistant in obtaining health manager qualifications, speech activities, etc., and actively promoting "preventive medicine."

Science

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• Shibnath Ghatak, Edward V. Maytin, Judith A. Mack, Vincent C. Hascall, Ilia Atanelishvili, Ricardo Moreno Rodriguez, Roger R. Markwald, Suniti Misra, “Roles of Proteoglycans and Glycosaminoglycans in Wound Healing and Fibrosis”, International Journal of Cell Biology, vol. 2015, Article ID 834893, 20 pages, 2015. https://doi.org/10.1155/2015/834893
• Pang X, Dong N and Zheng Z (2020). Small Leucine-Rich Proteoglycans in Skin Wound Healing. Front. Pharmacol. 10:1649. https://doi.org/10.3389/fphar.2019.01649
• Krawetz, R.J., Abubacker, S., Leonard, C. et al. Proteoglycan 4 (PRG4) treatment enhances wound closure and tissue regeneration. npj Regen Med 7, 32 (2022). https://doi.org/10.1038/s41536-022-00228-5
• Thiesen AP, Mielczarski B, Savaris RF (2023). Deep learning neural network image analysis of immunohistochemical protein expression reveals a significantly reduced expression of biglycan in breast cancer. PLoS ONE 18(3): e0282176. https://doi.org/10.1371/journal.pone.0282176
• Niedworok C, Röck K, Kretschmer I, Freudenberger T, Nagy N, et al. (2013) Inhibitory Role of the Small Leucine-Rich Proteoglycan Biglycan in Bladder Cancer. PLoS ONE 8(11): e80084. https://doi.org/10.1371/journal.pone.0080084
• Provenzale, I.; De Simone, I.; Gibbins, J.M.; Heemskerk, J.W.M.; van der Meijden, P.E.J.; Jones, C.I. Regulation of Glycoprotein VI-Dependent Platelet Activation and Thrombus Formation by Heparan Sulfate Proteoglycan Perlecan. J. Mol. Sci. 2023, 24, 13352. https://doi.org/10.3390/ijms241713352
• Asfari, A., Doyle, E. A., Jay, G. D., Aristizabal, N., Manchikalapati, A., Rahman, A. K. M. F., Hock, K. M., Borasino, S., Ambalavanan, N., Schmidt, T. A., & Rhodes, L. A. (2023). Plasma proteoglycan 4: a novel biomarker for acute lung injury after pediatric cardiac surgery. Translational pediatrics, 12(9), 1668–1675. https://doi.org/10.21037/tp-23-194
• Lv R, Duan L, Gao J, Si J, Feng C, Hu J and Zheng X (2023). Bioinformatics-based analysis of the roles of basement membrane-related gene AGRN in systemic lupus erythematosus and pan-cancer development. Immunol. 14:1231611. https://doi.org/10.3389/fimmu.2023.1231611
• Christopher Xie, Liliana Schaefer, Renato V. Iozzo, Global impact of proteoglycan science on human diseases, iScience, Volume 26, Issue 11, 2023, 108095, ISSN 2589-0042, https://doi.org/10.1016/j.isci.2023.108095
• Akio Nakane, Shouhei Hirose, Noriaki Kawai, Naoki Fujimoto, Eriko Kondo, Krisana Asano, Salmon nasal cartilage proteoglycan stimulates hair growth, Bioscience, Biotechnology, and Biochemistry, 2023;, zbad149, https://doi.org/10.1093/bbb/zbad149
• Martyniak, K.; Kennedy, S.; Karimzadeh, M.; Cruz, M.A.; Jeon, O.; Alsberg, E.; Kean, T.J. Optimizing Bioink Composition for Human Chondrocyte Expression of Lubricin. Bioengineering 2023, 10, 997. https://doi.org/10.3390/bioengineering10090997
• Jasti, P., Kumari, S., Singh, S., & Anudeep, P. P. (2023). Serum versican as a potential biomarker in patients with uterine fibroids: A study from Eastern India. Journal of family medicine and primary care, 12(8), 1704–1709. https://doi.org/10.4103/jfmpc.jfmpc_320_23
• Helwa-Shalom, O., Saba, F., Spitzer, E., Hanhan, S., Goren, K., Markowitz, S. I., Shilo, D., Khaimov, N., Gellman, Y. N., Deutsch, D., Blumenfeld, A., Nevo, H., & Haze, A. (2023). Regeneration of injured articular cartilage using the recombinant human amelogenin protein. Bone & joint research, 12(10), 615–623. https://doi.org/10.1302/2046-3758.1210.BJR-2023-0019.R1
• Buran, T., Batır, M.B., Çam, F.S. et al. Molecular analyses of ADAMTS-1, -4, -5, and IL-17 a cytokine relationship in patients with ulcerative colitis. BMC Gastroenterol 23, 345 (2023). https://doi.org/10.1186/s12876-023-02985-z
• El-Qashty, R., Elkashty, O.A. & Hany, E. Photobiostimulation conjugated with stem cells or their secretome for temporomandibular joint arthritis in a rat model. BMC Oral Health 23, 720 (2023). https://doi.org/10.1186/s12903-023-03466-1
• Choi, T.; Maiti, G.; Chakravarti, S. Three-Dimensional Modeling of CpG DNA Binding with Matrix Lumican Shows Leucine-Rich Repeat Motif Involvement as in TLR9-CpG DNA Interactions. J. Mol. Sci. 2023, 24, 14990. https://doi.org/10.3390/ijms241914990
• Renato V. Iozzo, Liliana Schaefer, Proteoglycan form and function: A comprehensive nomenclature of proteoglycans, Matrix Biology, Volume 42, 2015, Pages 11-55, ISSN 0945-053X, https://doi.org/10.1016/j.matbio.2015.02.003
• Bernard B. A. (2016). Advances in Understanding Hair Growth. F1000Research, 5, F1000 Faculty Rev-147. https://doi.org/10.12688/f1000research.7520.1
• Oravecz, O.; Balogh, A.; Romero, R.; Xu, Y.; Juhasz, K.; Gelencser, Zs.; Xu, Z.; Bhatti, G.; Pique-Regi, R.; Peterfia, B.; et al. Proteoglycans: Systems-Level Insight into Their Expression in Healthy and Diseased Placentas. J. Mol. Sci. 2022, 23, 5798. https://doi.org/10.3390/ijms23105798
• Bernard B. A. (2016). Advances in Understanding Hair Growth. F1000Research, 5, F1000 Faculty Rev-147. https://doi.org/10.12688/f1000research.7520.1
• Khramova, A., Boi, R., Fridén, V. et al. Proteoglycans contribute to the functional integrity of the glomerular endothelial cell surface layer and are regulated in diabetic kidney disease. Sci Rep 11, 8487 (2021). https://doi.org/10.1038/s41598-021-87753-3
• Wight T. N. (1989). Cell biology of arterial proteoglycans. Arteriosclerosis (Dallas, Tex.), 9(1), 1–20. https://doi.org/10.1161/01.atv.9.1.1